1. What is SHBG Ratio Calculator?

Definition: This calculator estimates the ratio of testosterone to sex hormone-binding globulin (SHBG), which represents the biologically active free testosterone.

Purpose: It helps medical professionals and individuals assess androgen status and potential testosterone activity in the body.

2. How Does the Calculator Work?

The calculator uses the formula:

Where:

• \( R \) — Testosterone/SHBG ratio (dimensionless)
• \( T \) — Testosterone level (nmol/L)
• \( SHBG \) — Sex hormone-binding globulin level (nmol/L)

Explanation: The testosterone level is divided by SHBG level to determine the ratio, which correlates with free testosterone activity.

3. Importance of SHBG Ratio

Details: The ratio helps evaluate androgen status when direct free testosterone measurement isn't available, and is useful in assessing conditions like hypogonadism or polycystic ovary syndrome.

4. Using the Calculator

Tips: Enter testosterone and SHBG levels in nmol/L. Both values must be > 0. The result is a unitless ratio.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal SHBG ratio range?
A: Typical ratios range from 0.1 to 0.8, but optimal ranges depend on age, sex, and clinical context.

Q2: Why is SHBG important in testosterone assessment?
A: SHBG binds to testosterone, making it inactive. Only unbound (free) testosterone is biologically active.

Q3: When would this ratio be clinically useful?
A: When evaluating symptoms of androgen excess or deficiency, especially when total testosterone levels are borderline.

Q4: How does this differ from free testosterone calculation?
A: This is a simpler approximation that correlates with but doesn't equal free testosterone percentage.

Q5: What factors affect SHBG levels?
A: SHBG is increased by estrogen, thyroid hormones, and liver health, and decreased by androgens, insulin resistance, and obesity.